PATHOPHYSIOLOGY OF HEPATITIS
The hepatitis A virus is a non-enveloped RNA virus. It is relatively resistant to the action of heat. Once the virus enters the body, it multiples in the intestinal epitheleum and escapes to the liver by the haematogenous route. products.herbalife.co.uk The hepatitis B virus is an enveloped DNA virus, possessing a double shelled spherical structure. This virus replicate in the liver cells and virus cells or their fragments get incorporated in the liver cell membranes. The manifestations of hepatitis B is mainly due to immune response to the infection and due to cytotoxicity of virus. Delta virus and Non-A and Non-B viruses and their pathophysiology is not well understood. Chronic hepatitis occurs as complication in around 5% of hepatitis patients. The massive hepatic necrosis occurs and liver suddenly shrinks over a period of several hours or days. The patient develops hepatic coma and around 0.1%-0.4% patient of hepatitis A and 10-12% of hepatitis B die.
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