MEDICINE THERAPY FOR MIGRAINE

Migraine is a mysterious disorder characterized by pulsating head ache, usually restricted to one side, which comes in attacks lasting 4 – 48 hours and is often associated with nausea, vomiting, sensitivity to light and sound, vertigo, loose motions. Migraineurs often suffer from cutaneous allodynia – that is, sensitivity and/or pain when the skin is touched. Most common in women, it often comes during the headache stage of a migraine attack (if there is a headache at all), but for many people it comes before, and is a kind of “warning signal”. The skin becomes so sensitive, that it may feel like your “hair hurts”. Running a comb through your hair can be excruciating. The most common medicine for severe migraine is Ergotamine. It is the most effective medicine. It should be given early in attack, relief is often drammatic and lower doses suffice. Patients who vomit can be given the drug per rectum as suppository. Parenteral administration should not be given because it is more hazards. Another class of drugs that might help is a cyclooxygenase inhibitor, a type of anti-inflammatory drug. There have been concerns about Cox2 inhibitors and their link to heart problems. The brand name is MIGRANIL, MIGRIL, VASOGRAIN. The larger dosage of the medicine is needed and control may be achieved only after few hours. Oral / sublingual route is preferred, 1 mg is given at ½ hour intervals or a total of 6 mg is given.

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